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60只麻醉开胸 SD大鼠 ,可逆结扎左冠状动脉主支 5 m in后解除结扎 6 0 m in,引发再灌注心律失常 (RA) ,动物分为生理盐水 (NS,10 m l/kg,ig)、维生素 (VE,5 0 0 m g/kg,ig)与超氧化物歧化酶 (SOD 5 0 0 0 U /kg,iv) 3组。用 RM-6 0 0 0多导生理记录仪监测 ECG 。结果 NS与 SOD组 RA总发生率均为 95 % ,V E组为 35 % (P<0 .0 0 1)。 N S,SO D及 VE组心室纤颤发生率与死亡率分别为 45 ,40 % ;5 0 ,2 5 % ;15 ,0 %。 V E组显著比 NS,SOD组低
Sixty anesthetized rats with thoracotomy were treated with reversible ligation of the main branch of the left coronary artery for 5 min followed by ligation of 60 min to induce reperfusion arrhythmia (RA). Animals were divided into normal saline (NS, 10 ml / kg, ig ), Vitamins (VE, 500 mg / kg, ig) and superoxide dismutase (SOD 5 0 0 0 U / kg, iv) The ECG was monitored with a RM-60 0 multi-channel physiology recorder. Results The overall incidence of RA was 95% in NS and SOD groups, 35% in VE group (P <0.001). The incidence and mortality of ventricular fibrillation in N S, SO D and VE groups were 45 and 40%, 50 and 25% and 15 and 0%, respectively. V E group was significantly lower than the NS, SOD group