论文部分内容阅读
目的 探讨慢性染铅过程中大鼠肾脏一氧化氮合酶 (NOS)、一氧化氮 (NO)的变化。方法 Wistar大鼠经饮水加 0 0、18 4、184 0mg/L醋酸铅 (PbAc)方法染毒。结果 高剂量组大鼠肾脏NOS活力 30d后低于对照组 (P <0 0 5 )。低剂量染铅组大鼠肾脏NOS活力 6 0d后低于对照组 (P <0 0 5 )。低剂量染铅组肾脏NO含量在各时间点上均有降低趋势 ,但差异无统计学意义 (P >0 0 5 )。高剂量组大鼠肾脏NO含量在 6 0d、90d后低于对照组 (P <0 0 5 )。结论 铅可导致肾脏NOS活力降低 ,NO含量降低 ,可能是铅对肾脏产生细胞毒作用的机制。
Objective To investigate the changes of nitric oxide synthase (NOS) and nitric oxide (NO) in rat kidney during chronic lead exposure. Methods Wistar rats were treated with 0 0,18 4,184 0 mg / L lead acetate (PbAc) by drinking water. Results The renal NOS activity in high dose group was lower than that in control group after 30 days (P <0.05). The renal NOS activity of low dose lead-exposed rats was lower than that of the control group after 60 days (P <0.05). The content of NO in kidney of low-dose lead-exposed group decreased at all time points, but the difference was not statistically significant (P> 0.05). The content of NO in the kidney of high-dose group was lower than that of the control group at 60 days and 90 days (P <0.05). Conclusion Lead can lead to the decrease of NOS activity and the decrease of NO in kidneys, which may be the mechanism of lead toxicity to kidneys.