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目的分析大剂量糖皮质激素早期治疗重度戊型黄疸型肝炎的疗效。方法选取2008年5月-2014年5月来成都市公共卫生临床医疗中心感染科就诊的重度戊型黄疸型肝炎的患者80例,将患者随机分为观察组和对照组,每组40例,比较两组临床疗效、不良反应情况及肝功能指标变化,并采用SPSS18.0进行统计分析。结果观察组的治愈率(97.5%)高于对照组(62.5%),差异有统计学意义(P<0.05);治疗1个月后观察组患者的肝功能指标恢复较对照组优,差异有统计学意义(P<0.05);两组患者在治疗期间均未产生严重的不良反应,无一例患者因用药不良反应而改变治疗方案。结论大剂量糖皮质激素早期治疗重度戊型黄疸型肝炎方临床疗效显著,值得临床推广应用。
Objective To analyze the curative effect of high dose glucocorticoid on early treatment of severe pentapeptide jaundice hepatitis. Methods A total of 80 patients with severe pentapeptide jaundice hepatitis treated in the Infectious Diseases Section of Chengdu Public Health Clinical Center from May 2008 to May 2014 were randomly divided into observation group and control group with 40 cases in each group. Clinical efficacy, adverse reactions and changes of liver function were compared between the two groups, and SPSS18.0 was used for statistical analysis. Results The cure rate of observation group was higher than that of control group (97.5%) (62.5%), the difference was statistically significant (P <0.05); After 1 month of treatment, the recovery of liver function index of observation group was better than that of control group Statistical significance (P <0.05). No adverse reactions were found in both groups during the treatment period. No patients changed their treatment regimens due to adverse drug reactions. Conclusion High-dose glucocorticoid early treatment of severe pentapeptide jaundice hepatitis side clinical significant effect, worthy of clinical application.