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已知霍乱弧菌的表面多糖与其免疫原性有关 ,如与蛋白共价结合可增强其免疫原性 ,作者介绍了两种制备 O1 39型霍乱弧菌荚膜多糖 ( CPS) -重组白喉毒素突变体CRMH2 1 G( r DT)结合疫苗的合成方法。 以 1 -乙基 - 3- ( 3-二甲胺基丙基 )碳化二亚胺 ( EDC)和 1 -氰 - 4 -二甲胺?
It is known that the surface polysaccharides of Vibrio cholerae are related to their immunogenicity, for example, covalently binding to proteins can enhance their immunogenicity. The authors introduced two kinds of preparations of Vibrio cholerae O1 39 capsular polysaccharide (CPS) - recombinant diphtheria toxin Methods for the synthesis of the CRMH2 1 G (r DT) conjugate vaccine. Using 1 - ethyl - 3- (3 - dimethylaminopropyl) carbodiimide (EDC) and 1 - cyano - 4 - dimethylamine?