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目的：探讨大鼠发育过程中海马ＣＡ１区ＬＴＰ的变化。方法：刺激海马ＣＡ３区Ｓｃｈａｆｆｅｒ侧枝，在ＣＡ１锥体细胞层记录ＬＴＰ。结果：１月龄大鼠海马ＣＡ１区ＬＴＰ诱出率最低，２、６月龄大鼠诱出率均高于１月龄大鼠；串刺激后，２月龄大鼠平均峰潜期显著缩短，而１、６月龄大鼠无明显变化；各年龄组大鼠ＰＳ峰值在串刺激后均明显增加，但１月龄大鼠ＰＳ增幅最小，２月龄大鼠ＰＳ增幅最大，ｆＥＰＳＰ斜率的变化与ＰＳ增幅的变化基本一致。结论：ＬＴＰ随发育进程有明显的变化，２月龄大鼠ＬＴＰ效应强于其他年龄组大鼠。
Objective: To investigate the changes of LTP in hippocampal CA1 area during the development of rats. Methods: Schaffer collaterals were stimulated in hippocampal CA3 region and LTP was recorded in CA1 pyramidal cell layer. Results: The LTP induced rate of hippocampus CA1 in 1-month-old rats was the lowest, while the induced rate in 2 and 6-month-old rats was higher than that in 1-month-old rats. The average peak latency of 2-month-old rats was significantly shortened , While there was no significant change in 1 and 6 month old rats. The PS peak of rats in each age group increased significantly after the stimulation of the skeletal muscle, but the amplitude of PS in 1-month-old rats was the smallest, the amplitude of PS in 2-month-old rats was the largest, and the slope of fEPSP Changes and PS changes in the same basic changes. CONCLUSION: LTP has a significant change with the developmental process, LTP effect in 2-month-old rats is stronger than that in other age groups.