论文部分内容阅读
目的 探讨微血管数和cyclinE、p53、CD4 4s、CD4 4v6的表达分别预测胃癌预后的作用。方法 以免疫组化法检测了 95例胃癌的上述 5指标 ,并同时检测了临床病理特征 ,然后研究了各个因素分别与预后和淋巴、静脉侵润的关系。结果 微血管数和cyclinE表达显著影响胃癌的预后。p53、CD4 4s、CD4 4v6的表达不显著影响预后。微血管数是显著独立的预后因素。微血管每增 1支 ,淋巴管浸润的相对危险度都为增前的 1 0 314倍 (P <0 0 5)。p53阳性癌淋巴结转移的相对危险度是阴性者的 2 2 4 0 3倍 (P <0 0 5)。 5个指标的过度表达或增高未使胃癌浸润静脉的相对危险度显著增高。结论 在胃癌中 ,微血管数是预测预后的重要指标 ,cyclinE表达也有一定预测作用 ,而p53、CD4 4s、CD4 4v6的表达无预后判断意义。
Objective To investigate the role of microvessel density and the expression of cyclinE, p53, CD4 4s and CD4 4v6 in predicting the prognosis of gastric cancer. Methods The immunohistochemical method was used to detect the above 5 indicators of 95 cases of gastric cancer. Simultaneously, the clinicopathological features were detected. Then the relationship between each factor and prognosis and lymphatic invasion was studied. Results The number of microvessels and cyclinE expression significantly affected the prognosis of gastric cancer. The expression of p53, CD4 4s, and CD4 4v6 did not significantly affect the prognosis. The number of microvessels is a significant independent prognostic factor. For each increase of microvessels, the relative risk of lymphatic vessel invasion was 1 0 314 times that before the increase (P < 0 05). The relative risk of lymph node metastasis in p53-positive cancer was 2 430 times (P <0 05). The over-expression or increase of five indicators did not significantly increase the relative risk of gastric cancer infiltrating veins. Conclusion In gastric cancer, the number of microvessels is an important predictor of prognosis, and cyclinE expression also has a certain predictive effect. The expression of p53, CD4 4s and CD4 4v6 has no prognostic significance.