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目的:研究七叶皂苷钠对肺部急性炎性渗出的作用。方法:以乙酸所致的腹腔毛细血管通透性增高模型小鼠观察七叶皂苷钠对急性渗出作用的时效关系;以肾上腺素致大鼠急性肺水肿和内毒素致小鼠急性肺损伤模型,观察七叶皂苷钠对急性肺部炎症渗出的影响。结果:七叶皂苷钠抑制急性炎症渗出作用的起效较慢,给药5 h后作用开始较为明显,作用可持续24 h;预防给药,可明显降低急性肺水肿大鼠的死亡率;对肾上腺素及内毒素所致肺部炎症也有明显抑制作用。结论:七叶皂苷钠可用于急性肺炎中肺部急性炎症渗出的防治。
Objective: To study the effect of sodium aescinate on acute inflammatory exudation in the lungs. Methods: To observe the time-effect relationship of sodium aescinate on acute exudative effect in acetic acid-induced mouse models of acute hypersensitivity induced by peritoneal capillary permeability in mice with acute pulmonary edema and endotoxin-induced acute lung injury , To observe the effect of sodium aescinate on exudation of acute lung inflammation. Results: Sodium aescinate had a slower onset of acute exudative inflammation. After 5 h of administration, the effect began to be obvious and the effect lasted for 24 h. The prophylaxis of sodium aescinate significantly reduced the mortality of rats with acute pulmonary edema. On the adrenergic and endotoxin-induced lung inflammation also had a significant inhibitory effect. Conclusion: Sodium aescinate can be used in the prevention and treatment of acute inflammatory exudation of lung in acute pneumonia.