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目前为了解妇女原因不明不孕的病因及开创免疫避孕法,从生殖免疫学对阻止受精的特异性抗体的研究已被关注。有关抗透明带抗体已有许多报告。本文重点讨论实验性卵巢炎的病理、抗卵细胞抗体及其产生机制。一、实验性卵巢炎的经过和病理:小鼠的性周期从出生后35～40日开始,约4～5日为一个周期。若于出生后3日摘除胸腺,则全部无发情期,或数次规律的性周期后出现周期紊乱,至60～90日龄时发情停止,摘除胸腺的小鼠全部不孕。此时卵巢外观明显萎缩,镜下或多或少有淋巴细胞浸润,卵泡及黄体消失,多数为间质细胞所占据,也可见到全部为结缔组织的极度萎缩的卵巢。如以卵细胞数
At present, in order to understand the etiology of unexplained infertility due to women’s causes and to create an immunocontraceptive method, research on specific antibodies to prevent fertilization from genital immunology has drawn attention. There are many reports on anti-zona pellucida antibodies. This article focuses on the pathology of experimental oophoritis, anti-egg antibody and its mechanism. First, the experimental ovarian inflammation and pathology: the mouse’s sexual cycle from 35 to 40 days after birth, about 4 to 5 days for a cycle. If the removal of the thymus on the 3rd after birth, all without estrus, or several regular cycles after the cycle disorders, to 60 to 90 days of age, estrus to stop, remove all the thymus mice infertility. At this point a marked decline in the appearance of the ovary, microscopic infiltration of more or less lymphocytes, follicles and corpus luteum disappeared, mostly occupied by interstitial cells, but also to see all the extremely shrinking connective tissue of the ovary. If the number of eggs