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目的 :研究益气化瘀煎剂对大鼠实验性胃溃疡的防治作用 ,并对其机制进行探讨。方法 :观察预先应用中药对应激、乙醇、消炎痛、幽门结扎所诱发的胃粘膜损伤的影响 ;并观察连续应用中药 8、18和 2 6d后 ,醋酸性胃粘膜损伤的愈合情况 ;检测胃壁结合粘液、胃组织DNA、胃粘膜超氧化物歧化酶 (SOD)、丙二醛 (MDA)及前列腺素E2 (PGE2 )的含量。结果 :益气化瘀煎剂显著抑制应激、乙醇及消炎痛性胃粘膜损伤 (P <0 .0 5 ,<0 0 1) ,并具有剂量依赖关系 ;加速胃溃疡的愈合 ,其疗效与雷尼替丁接近。同时 ,增加胃粘膜组织DNA、SOD及PGE2 的含量 ,减低MDA的生成。结论 :益气化瘀煎剂具有较强防治胃溃疡的作用 ,其机制可能主要是增强胃粘膜细胞保护作用。
Objective : To study the preventive and therapeutic effects of Yiqi Huayu decoction on experimental gastric ulcer in rats and its mechanism. Methods: Observed the effect of pre-application of traditional Chinese medicine on gastric mucosal injury induced by stress, ethanol, indomethacin, and pylorus ligation; and observed the healing of acetic acid-induced gastric mucosal injury after continuous application of traditional Chinese medicine for 8, 18, and 26 days; Mucus, gastric tissue DNA, gastric mucosal superoxide dismutase (SOD), malondialdehyde (MDA), and prostaglandin E2 (PGE2) content. Results: Yiqi Huayu decoction significantly inhibited the stress, ethanol and indomethacin induced gastric mucosal injury (P < 0.05, <0 01), and had a dose-dependent relationship; Accelerated healing of gastric ulcer, and its curative effect Ranitidine is close. At the same time, increased gastric mucosal tissue DNA, SOD and PGE2 content, reduce the production of MDA. Conclusion : Yiqi Huayu decoction has a stronger effect on preventing and treating gastric ulcer, and its mechanism may be mainly to enhance the protective effect of gastric mucosal cells.