论文部分内容阅读
环孢素A(CsA)是一种良好的免疫抑制剂,可提高移植器官的存活,减少排斥反应和感染;但是它具有与剂量有关的肾毒性作用,并且还能引起移植肾的血管损伤,内皮细胞的破坏和增殖,出现类似于溶血性尿毒症综合征或血栓性血小板减少性紫癜的膨胀综合征(Full blown syndrome)。其结果促使移植器官功能丧失、血小板减少和微血管病变性贫血。本文采用~(111)铟(~(111)In) 标记的自体血小板经扫描检查来早期识别肾移植患者CsA所致的动脉病变,以便及时停药和采用相应的治疗使病变得以逆转。作者报告200例应用CsA和强的松治疗的肾移植受者采用~(111)In血小板扫描,其中100例系移植肾功能正常者于出院前,另100例因移植肾功能障碍者于再次
Cyclosporine A (CsA) is a good immunosuppressive agent that increases the survival of transplanted organs and reduces rejection and infection; however, it has dose-related nephrotoxic effects and can also cause vascular damage in transplant kidneys, The destruction and proliferation of endothelial cells results in a full blown syndrome similar to hemolytic uremic syndrome or thrombotic thrombocytopenic purpura. The results prompted the loss of organ function, thrombocytopenia and microangiopathy. In this paper, ~ (111) indium (~ (111) In) autologous platelets were scanned to identify the arterial lesions caused by CsA in renal transplant patients in order to promptly stop the treatment and the corresponding treatment can be used to reverse the disease. The authors reported 200 cases of renal transplant recipients treated with CsA and prednisone using ~ (111) In platelet scan, of which 100 cases of normal renal transplant recipients before discharge, and the other 100 due to renal transplant recipients