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实验和临床资料提示,血小板可促使冠心病患者的病情发展。猝死后的心脏剖验显示,在冠状动脉微循环内有血小板集聚。血小板因子4(PF-4)是血小板集聚时释出的一种蛋白,可作为体内血小板激活的指标。近来发现急性心肌梗塞和稳定型冠心病患者的血浆 PF-4可升高。为此,作者应用 PF-4放射免疫测定研究血浆 PF-4水平与运动引起心肌缺血之间的关系,并用以观察心绞痛发作时是否
Experimental and clinical data suggest that platelets can promote the development of patients with coronary heart disease. Cardiac dissection after sudden death revealed platelet aggregation within the coronary microcirculation. Platelet factor 4 (PF-4) is a protein released during platelet aggregation as an indicator of platelet activation in vivo. Recently, patients with acute myocardial infarction and stable coronary heart disease PF-4 may be elevated. To this end, the authors apply PF-4 radioimmunoassay to study the relationship between plasma PF-4 levels and exercise-induced myocardial ischemia and to assess whether angina attacks occur