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自人肺成纤维细胞以逆转录－ＤＮＡ聚合酶链式反应（ＲＴ－ＰＣＲ）钓取了人成纤维细胞生长因子受体１（ＦＧＦＲ１）细胞外段（含第２和第３免疫球蛋白结构域）ｃＤＮＡ。将此片段标记成非同位素探针，用其与ＳａｌⅠ消化的小鼠心脏等组织的基因组ＤＮＡ进行了Ｓｏｕｔｈｅｒｎ印迹杂交。结果表明：与其它组织相比，成年小鼠心脏组织显示ＦＧＦＲ１基因Ｓｏｕｔｈｅｒｎ印迹的带型发生了变化。经过分析，提出了产生这种变化的３种模式。
Fibroblast growth factor receptor 1 (FGFR1) extracellular domain (including the second and third immunoglobulin structures) was captured from human lung fibroblasts by reverse transcription-DNA polymerase chain reaction (RT-PCR) Domain) cDNA. This fragment was labeled as a non-isotopic probe and Southern blot hybridization was performed with genomic DNA of SalI-digested mouse heart and the like. The results showed that the adult mouse heart tissue showed a change in the banding pattern of the Southern blot of the FGFR1 gene compared with other tissues. After analysis, proposed three kinds of patterns that produce this kind of change.