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目的：为适应乳腺癌诊断与治疗的进展，通过提供客观的形态学依据，以达到最佳治疗的目的。方法：对１４０例妇女乳腺癌根治术标本根据肿瘤始发组织学部位、形态特点、分化程度、组织结构、肿瘤进展的动态过程、形态与功能变异、瘤细胞核ＤＮＡ含量及生物学行为进行了组织学分类。部分切片采用Ｓ－Ｐ法免疫组化染α－ｓｍｏｏｔｈｍｕｓｃｌｅａｃｔｉｎ（α－ＳＭＡ），观察导管肌上皮、基底膜破坏和癌巢周围肌纤维母细胞反应性增生用以辅助分类，９０例不同组织类型的癌切片做Ｆｅｕｌｇｅｎ染色，用ＣＭＩＡＳⅡ图像分析观察瘤细胞核ＤＮＡ含量。结果：把乳腺癌分成导管癌、小叶癌、化生性癌和特殊类型的癌４大类，根据肿瘤连续进展的动态过程和组织结构每类又分成若干小类。不同组织类型瘤细胞ＤＮＡ含量统计学处理差异显著，提示每组类型有各自生物学的独特性，分类合理。结论：分类为临床选择最佳治疗方案提供了有益的形态学依据
Objective: To meet the progress of diagnosis and treatment of breast cancer by providing objective morphological evidence to achieve the best therapeutic goals. METHODS: A total of 140 women undergoing radical mastectomy were organized according to histological site, morphological features, differentiation, tissue structure, dynamic process of tumor progression, morphological and functional variation, nuclear DNA content of tumor cells, and biological behavior. Classification. Some sections were immunohistochemically stained for α-smoothmuscleactin (α-SMA) by S-P method, and the vessel myoepithelium, basement membrane destruction, and reactive hyperplasia of myofibroblasts around the cancer nest were used to assist classification. Ninety cases of cancer of different tissue types were used. The sections were stained with Feulgen and the nuclear DNA content of the tumor cells was observed by CMIASII image analysis. Results: Breast cancer was divided into four categories: ductal carcinoma, lobular carcinoma, metaplastic carcinoma, and special type of carcinoma. According to the dynamic progression of the tumor and its organizational structure, each category was divided into several subcategories. There were significant differences in the statistical processing of tumor cell DNA content in different tissue types, suggesting that each group type has its own unique biology and reasonable classification. Conclusion: Classification provides a useful morphological basis for clinical selection of optimal treatment plan