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目的:探讨糖化血红蛋白与血清胱抑素C的检测在糖尿病肾病早期诊断中的意义。方法:应用高效液相色谱法与免疫比浊法分别对120例初诊为糖尿病早期肾病患者测定糖化血红蛋白与血清胱抑素C,并根据糖化血红蛋白水平分为低、中、高值3组,对各组结果进行统计学分析。结果:各组间糖化血红蛋白增高的同时,胱抑素C也增高,各组相同指标间的差异均有统计学意义(P均<0.05)。结论:检测糖化白红蛋白水平可以有效判断糖尿病及其早期肾病的进程;白清胱抑素C的测定为临床及时发现和诊断早期肾病提供了可靠依据。
Objective: To investigate the significance of detecting glycated hemoglobin and serum cystatin C in the early diagnosis of diabetic nephropathy. Methods: HbA1c and serum cystatin C were determined in 120 patients with newly diagnosed diabetic nephropathy by high performance liquid chromatography and immunoturbidimetry respectively. According to the levels of glycosylated hemoglobin, they were divided into three groups: low, medium and high. The results of each group were statistically analyzed. Results: The levels of HbA1c increased at the same time among the three groups, and the differences among the same indexes in each group were statistically significant (all P <0.05). Conclusion: The detection of glycosylated hemoglobin level can effectively determine the progression of diabetes and its early nephropathy. The determination of serum cystatin C provides a reliable basis for clinical timely detection and diagnosis of early nephropathy.