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目的:探讨急性冠脉综合征(ACS)病人与高敏反应C蛋白(hs-CRP)水平及颈动脉超声检查变化及其相关性。方法:将109例观察对象分为病例组(急性冠脉综合征,56例)和对照组(53例)。采用酶联免疫吸附法(ELISA)检测血清hs-CRP水平。使用多谱勒超声检查颈动脉内-中膜厚度(IMT)及斑块发生率。同时将109例观察对象分为hs-CRP≤3 mg/L组(43例)和hs-CRP>3 mg/L组(66例),分析hs-CRP与IMT的关系。结果:病例组血清hs-CRP(4.72±2.55)mg/L明显高于对照组(1.85±0.79)mg/L,差异具有统计学意义(P<0.01)。病例组颈动脉内-中膜厚度(1.82±0.66)mm,明显厚于对照组(1.01±0.40)mm,斑块发生率(85.7%)高于对照组(35.8%),差异均具有统计学意义(P<0.001)。hs-CRP>3 mg/L组IMT为(1.80±0.63)mm,斑块发生率为83.7%,急性冠脉综合征发生率为83.7%;hs-CRP≤3 mg/L组IMT为(1.17±0.59)mm,斑块发生率为37.9%,急性冠脉综合征发生率为30.3%,2组比较差异均具有统计学意义。血清hs-CRP水平与IMT厚度呈正相关(rs=0.434,P<0.05)。结论:血清hs-CRP水平可作为反映急性冠脉综合征患者的敏感标志物,颈动脉粥样硬化程度可以反映急性冠脉综合征的斑块不稳定性,炎症反应可能参与颈动脉硬化形成。
Objective: To investigate the changes of hs-CRP and carotid ultrasonography in patients with acute coronary syndrome (ACS) and its correlation. Methods: 109 cases were divided into case group (acute coronary syndrome, 56 cases) and control group (53 cases). Serum hs-CRP level was detected by enzyme-linked immunosorbent assay (ELISA). Doppler echocardiography was used to examine carotid intima-media thickness (IMT) and plaque incidence. 109 cases were divided into hs-CRP≤3 mg / L group (43 cases) and hs-CRP> 3 mg / L group (66 cases), the relationship between hs-CRP and IMT was analyzed. Results: The serum hs-CRP level in the case group was significantly higher than that in the control group (4.72 ± 2.55 mg / L vs 1.85 ± 0.79 mg / L, P <0.01). The carotid intima - media thickness (1.82 ± 0.66) mm in the case group was significantly thicker than that in the control group (1.01 ± 0.40) mm, and the plaque incidence rate was 85.7% (35.8%). The differences were statistically significant Significance (P <0.001). The IMT of hs-CRP> 3 mg / L group was (1.80 ± 0.63) mm, the plaque incidence was 83.7% and the incidence of acute coronary syndrome was 83.7%. The IMT of hs-CRP≤3 mg / ± 0.59) mm, the incidence of plaque was 37.9%, and the incidence of acute coronary syndrome was 30.3%. The differences between the two groups were statistically significant. Serum hs-CRP levels and IMT thickness was positively correlated (rs = 0.434, P <0.05). Conclusion: The level of serum hs-CRP can be used as a sensitive marker of acute coronary syndrome. The degree of carotid atherosclerosis can reflect the plaque instability of acute coronary syndrome. Inflammatory reaction may be involved in the formation of carotid atherosclerosis.