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目的探讨血清降钙素原(PCT)对脑损伤患者发生多器官功能障碍综合征(MODS)的早期诊断价值。方法 67例严重脑损伤患者,在入重症监护室24 h内测定血清PCT水平,根据其血清PCT水平分为A组(PCT≥0.5μg/L,33例)与B组(PCT<0.5μg/L,34例),并记录其C反应蛋白(CRP)、急性生理学与慢性健康状况Ⅱ(APACHEⅡ)评分,比较两组CRP、APACHEⅡ的差异,并分析其与PCT的关系。结果 A组和B组各有20例和4例发展为MODS,A组明显多于B组(P<0.05)。A组APACHEⅡ评分与CRP明显高于B组(P<0.05)。血清PCT水平与APACHEⅡ评分、CRP均呈正相关(r=0.536、0.689,P<0.05)。结论检测血清PCT对预测脑损伤患者发生MODS具有重要的早期诊断价值。
Objective To investigate the value of serum procalcitonin (PCT) in early diagnosis of multiple organ dysfunction syndrome (MODS) in patients with brain injury. Methods Sixty-seven patients with severe brain injury were enrolled in the intensive care unit (ICU). Serum PCT levels were determined within 24 hours according to their serum PCT levels. Group A (PCT≥0.5μg / L, 33 cases) and B group (PCT <0.5μg / L, 34 cases). The CRP, APACHEⅡ scores were recorded. The differences of CRP and APACHEⅡ between the two groups were compared and analyzed. Results 20 and 4 cases developed MODS respectively in group A and group B, and more in group A than in group B (P <0.05). APACHE Ⅱ score and CRP in group A were significantly higher than those in group B (P <0.05). Serum PCT levels and APACHE Ⅱ score, CRP were positively correlated (r = 0.536,0.689, P <0.05). Conclusion Detecting serum PCT has important early diagnostic value in predicting MODS in patients with brain injury.