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易于取材并具有多向分化潜能的骨髓间充质干/祖细胞已成为细胞/基因治疗及组织工程的优选种子细胞之一,探索获取具有更强自我更新能力及多向分化潜能均质细胞群的方法将进一步推进并完善其临床应用。Colter等发现在骨髓间充质干/祖细胞克隆群中除了纺锤型及扁平细胞外,还含有一种非常小的圆形细胞(RS细胞)。该细胞与上述两类细胞相比具有更强的自我更新能力及多向分化潜能,并且表达与成熟细胞不同的特殊蛋白和表面抗原,提示该类细胞用于体内长期移植或细胞治疗更具明显优势。本文围绕RS细胞的研究进展做一回顾,并对其未来的应用前景寄予展望。
Bone marrow mesenchymal stem / progenitor cells, which are easy to be drawn and have multi-directional differentiation potential, have become one of the preferred seed cells for cell / gene therapy and tissue engineering. The purpose of this study is to explore a method to obtain a homogeneous cell population with stronger self-renewal ability and multi-directional differentiation potential Approach will further promote and improve its clinical application. Colter et al. Found a very small round cell (RS cell) in addition to spindle and flat cells in the mesenchymal stem / progenitor clonal population. Compared with the above two types of cells, the cells have more self-renewal ability and multidirectional differentiation potential, and express special proteins and surface antigens different from those of mature cells, suggesting that such cells are more obvious for long-term transplantation or cell therapy in vivo Advantage. This article reviews the progress of RS cell research and looks forward to its future application prospects.