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目的观察静脉应用地尔硫卓治疗不稳定型心绞痛患者的疗效,安全性及不良反应。方法35例不稳定型心绞痛患者,首剂10mg静脉推注,继而以60μg/min静脉滴注,逐渐加量最大剂量300μg/min持续静脉滴注48h并观察心绞痛发作情况,心电图改变及血压、心率变化。结果用药后48h内与用药前比较,平均心绞痛发作次数减少,心电图缺血性表现明显改善,血压下降,心率减慢,出现窦性心动过缓2例,低血压1例,减量后恢复。结论短期静脉应用地尔硫卓安全,有效。
Objective To observe the efficacy, safety and adverse reactions of intravenous diltiazem in patients with unstable angina pectoris. Methods 35 patients with unstable angina pectoris were injected intravenously with the first dose of 10 mg and then intravenously dripped at 60 μg / min. The maximum dose of 300 μg / min was given intravenously for 48 hours. Angina pectoris, ECG changes, blood pressure, heart rate Variety. Results Compared with before treatment, the average number of angina attacks decreased, the electrocardiographic ischemic performance was significantly improved, the blood pressure was decreased and the heart rate was slowed down. There were 2 cases of sinus bradycardia and 1 case of hypotension. Conclusions Diltiazem in short-term intravenous use is safe and effective.