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Magnetite (Fe3O4) nanoparticles with different magnetic properties were prepared by coprecipitation of Fe3+ and Fe2+ with aqueous NaOH solution. The inductive heat properties of Fe3O4 nanoparticles in an alternating current (AC) magnetic field were investigated for local hyperthermia. The maximum saturation magnetization Ms of Fe3O4 nanoparticles is 65.53 emu·g-1 under the optimum conditions of Fe3+: Fe2+ molar ratio at 1.8:1. The Ms of Fe3O4 nanoparticles decreased as the Fe3+/Fe2+ molar ratio increased. But the coercivity Hc increases with the increasing of Fe3+/Fe2+ molar ratio. Exposed in the AC magnetic field for 29 min, the temperatures of physiological saline suspension containing Fe3O4 nanoparticles were 42-97.5 ℃. The inductive heat property of Fe3O4 nanoparticles in AC magnetic field decreases as Hc increases, but increases with the increasing of Ms. The Fe3O4 nanoparticles would be useful as good thermoseeds for localized hyperthermia treatment of cancers.
Magnetite (Fe3O4) nanoparticles with different magnetic properties were prepared by coprecipitation of Fe3 + and Fe2 + with aqueous NaOH solution. The maximum energy of magnetic properties of Fe3O4 nanoparticles in an alternating current (AC) magnetic field were investigated for local hyperthermia. Fe3O4 nanoparticles is 65.53 emu · g-1 under the optimum conditions of Fe3 +: Fe2 + molar ratio at 1.8: 1. The Ms of Fe3O4 nanoparticles decreased as the Fe3 + / Fe2 + molar ratio increased. But the coercivity Hc increases with the increasing of Fe3 + / Fe3 + Fe2 + molar ratio. Exposed in the AC magnetic field for 29 min, the temperatures of physiological saline suspension containing Fe3O4 nanoparticles were 42-97.5 ° C. The inductive heat property of Fe3O4 nanoparticles decreases in AC magnetic field as Hc increases, but increases with the increasing of Ms. The Fe3O4 nanoparticles would be useful as good thermoses for localized hyperthermia treatment of cancers.