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本文观察了24例肝硬化血浆氨基酸和胰岛素浓度的动态变化,其中胎肝输注组16人,一般内科治疗组8人。结果胎肝输注组,支链氨基酸在输注后较前明显增高,缬氨酸增加13.8％,亮氨酸增加15.21％,异亮氨酸增加18.86％。支链氨基酸与芳香族氨基酸的比值虽见增高,但统计学处理差异无显著性,芳香族氨基酸和胰岛素浓度保持不变。一般内科治疗组,支链氨基酸、芳香族氨基酶、胰岛素浓度均无改变。因此,我们认为胎肝输注后,能提高血浆支链氨基酸浓度,后者增加能提供能源,减少肌肉分解,并能促进肝脏蛋白质的合成,胎肝输注无明显副作用,且有一定疗效,可作为肝硬化的一种治疗方法。
In this paper, 24 patients with liver cirrhosis plasma amino acid and insulin concentration dynamic changes, including fetal liver infusion group of 16 people, general medical treatment group of 8 people. Results Fetal liver transfusion group, branched chain amino acids significantly increased after infusion, valine increased 13.8%, leucine increased 15.21%, isoleucine increased 18.86%. Although the ratio of branched-chain amino acids to aromatic amino acids increased, there was no significant difference in statistical analysis. The concentrations of aromatic amino acids and insulin remained the same. General medical treatment group, branched-chain amino acids, aromatic amino enzyme, insulin concentration were not changed. Therefore, we believe that after fetal liver infusion, can increase the plasma concentration of branched-chain amino acids, the latter to provide energy to increase, reduce muscle breakdown, and can promote liver protein synthesis, fetal liver infusion no significant side effects, and have a certain effect, Can be used as a treatment of cirrhosis.