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目的：探讨孕妇和葡萄胎患者红细胞膜ＡＴＰ酶活性的变化。方法：采用Ｒｅｉｎｉｌａ制膜法测定１０４例孕妇、３２例葡萄胎患者红细胞膜Ｎａ＋·Ｋ＋ＡＴＰ酶和Ｃａ２＋·Ｍｇ２＋ＡＴＰ酶含量。结果：孕妇组孕＜３个月和孕３～６个月两种酶活性与正常人差异无显著性（Ｐ＞０．０５）。孕＞６个月Ｎａ＋·Ｋ＋ＡＴＰ酶活性与正常人差异有显著性（Ｐ＜０．０１）；但Ｃａ２＋·Ｍｇ２＋ＡＴＰ酶活性差异无显著性（Ｐ＞０．０５）。葡萄胎患者两种酶活性均显著地低于正常人（Ｐ＜０．０１）。其含量的高低与血清中βｈＣＧ含量显著升高有关。葡萄胎患者红细胞膜ＡＴＰ酶含量与βｈＣＧ含量呈负相关（ｒ＝－０．５１，Ｐ＜０．０１）。结论：测定孕妇和葡萄胎患者红细胞膜ＡＴＰ酶活性变化对其发病机理和临床鉴别诊断有一定价值
Objective: To investigate the changes of erythrocyte membrane ATPase activity in pregnant women and hydatidiform mole patients. Methods: The contents of Na + · K + -ATPase and Ca2 + · Mg2 + -ATPase in erythrocyte membrane of 104 pregnant women and 32 cases of hydatidiform mole were detected by Reinila membrane method. Results: There was no significant difference in the activity of the two enzymes in pregnant women <3 months and 3 ~ 6 months pregnant with normal subjects (P> 0.05). The activity of Na + · K + ATP in pregnant> 6 months was significantly different from that in normal people (P <0.01), but there was no significant difference in Ca2 + · Mg2 + ATPase activity between the two groups (P> 0.05). The activity of the two enzymes in hydatidiform mole was significantly lower than that in normal people (P <0.01). The level of serum β hh CG content was significantly higher. Moles in patients with erythrocyte membrane ATPase content and β hCG content was negatively correlated (r = -0.51, P <0.01). Conclusion: The changes of ATPase activity of erythrocyte membrane in pregnant women and hydatidiform mole have certain value on the pathogenesis and clinical differential diagnosis