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目的观察和分析慢性心力衰竭(CHF)患者中性粒细胞百分比与抑郁程度的相关性。方法纳入住院CHF患者,采用汉密顿抑郁量表(HAMD)评估抑郁程度,并测定血清学相关指标。按照患者有无抑郁障碍分为2组:抑郁组(n=105)和非抑郁组(n=78),两组间显著差异的因素带入Logistic回归进行校正。结果单因素分析中发现两组心功能分级、中性粒细胞百分比、总胆固醇、低密度脂蛋白胆固醇和血肌酐存在显著差异。多因素Logistic回归分析显示心功能分级、总胆固醇和中性粒细胞百分比是抑郁障碍患者的独立相关因素。结论中性粒细胞百分比是CHF并发抑郁障碍的独立相关因素。
Objective To observe and analyze the correlation between the percentage of neutrophils and the degree of depression in patients with chronic heart failure (CHF). Methods Inpatients with CHF were enrolled in this study. HAMD was used to assess the severity of depression and the serological markers were determined. Patients were divided into two groups according to whether they had depression or not: depression (n = 105) and non-depression (n = 78). Logistic regression was used to correct the significant differences between the two groups. Results In the univariate analysis, there were significant differences in cardiac function classification, neutrophil percentage, total cholesterol, low density lipoprotein cholesterol, and serum creatinine. Multivariate Logistic regression analysis showed that the classification of cardiac function, total cholesterol and neutrophil percentage were independently associated with depressive disorder. Conclusions The percentage of neutrophils is an independent factor related to depressive disorder in CHF.