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目的 研究星形细胞瘤常规MRI增强程度与肿瘤血管生成的关系。方法 术前对32例星形细胞瘤行常规钆-喷替葡甲胺剂量(Gd-DTPA, 0. 1mmol·kg-1 )增强MRI检查, T1WI观察肿瘤增强情况。与脑室内脉络丛比较,肿瘤增强情况分为无/轻微、中等及明显强化3组。术后常规病理学检查,并用VIII因子相关抗原单克隆抗体对手术标本进行微血管免疫组织化学染色,用微血管记数(MVC)评定肿瘤血管生成。用Pearson相关分析,考察增强程度与血管生成的相关性。结果 32例星形细胞瘤中,术前常规增强MRT1WI上, 13例明显强化, 12例中等强化, 7例无/轻微强化。32例星形细胞瘤手术标本MVC7~113个,平均(46. 1±14. 3)个。其中明显强化组MVC为(56. 0±10. 7)个;中等强化组(38. 3±11. 9)个;无/轻微强化组(12. 5±6. 3)个。统计学相关分析表明:星形细胞瘤常规增强MRI增强程度与MVC存在显著正相关(r=0.763,Ρ<0. 01)。结论 星形细胞瘤常规MRI增强程度与肿瘤血管生成有关,常规MRI增强扫描可能在评价肿瘤血管生成方面有价值。
Objective To study the relationship between enhancement of routine MRI and tumor angiogenesis in astrocytomas. Methods Thirty-two patients with astrocytoma underwent preoperative Gd-DTPA (0.1 mmol · kg-1) dose-contrast MRI and T1WI was used to observe the tumor enhancement. Compared with intracerebral choroid plexus, tumor enhancement was divided into no / mild, moderate and significantly enhanced 3 groups. Postoperative routine pathological examination, and immunohistochemical staining of the specimens with monoclonal antibody against factor VIII-associated antigen, and angiogenesis by microvessel count (MVC). Pearson correlation analysis was used to examine the correlation between enhancement and angiogenesis. Results In 32 cases of astrocytoma, preoperative enhancement of MRT1WI, 13 cases were significantly enhanced, 12 cases of moderate enhancement, 7 cases without / slight enhancement. 32 cases of astrocytoma surgical specimens MVC7 ~ 113, an average of (46.1 ± 14.3) months. Among them, MVC in the group of significant enhancement was (56. 0 ± 10. 7), that in the group of moderate enhancement (38.3 ± 11.9), and that in the group without / the slight enhancement (12.5 ± 6.3). Statistical analysis showed that: astrocytoma enhanced MRI enhancement and there is a significant positive correlation (r = 0.763, P <0.01). Conclusion Conventional MRI enhancement of astrocytoma is related to tumor angiogenesis. Conventional MRI enhanced MRI may be valuable in evaluating tumor angiogenesis.