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本研究的目的是在中年男子中观察禁食情况下吸烟后烟碱对安静时能量消耗 (restingenergyexpendi ture ,REE)和血浆儿茶酚胺浓度的影响 ;并且在正常体重 (BMI≤ 2 5kg/m2 )和超重 (BMI >2 5kg/m2 )吸烟者之间比较吸烟引起的REE和血浆儿茶酚胺的急性反应是否有差别。对 32名禁食的男性吸烟者用间接测热法分别在吸烟前和吸 2支含 0 16mg烟碱 (低烟碱 )或 2支含 1 74mg烟碱 (高烟碱 )香烟 30min后测定REE ,同时测定血浆中烟碱和去甲肾上腺素浓度。正常体重组在吸低烟碱烟后和超重组不论在吸低烟碱烟或高烟碱烟后 ,REE和血浆儿茶酚胺均无明显改变。而在正常体重组中 ,吸高烟碱烟后血浆去甲肾上腺素浓度升高 ,同时REE增加7 2 % ;如果将血浆烟碱水平作为一个共变量进行分析 ,则吸烟后血浆去甲肾上腺素浓度和REE的改变也不明显 ,表明吸烟后的生热效应是因血浆烟碱浓度升高而引起的。体重对烟碱的生热效应能发生影响 ,在超重的吸烟者中烟碱的生热效应减弱。由此推测 ,正常体重的吸烟者在戒烟后 ,由于不再有吸烟引起的耗能生热 ,可能导致体重增加
The purpose of this study was to observe the effect of nicotine after smoking on restful energy expenditure (REE) and plasma catecholamine levels in fasting men under middle-aged conditions, and to observe the effects of nicotine on the body weight (BMI≤25kg / m2) and Is there any difference in the acute reactions between REE and plasma catecholamines caused by smoking in overweight (BMI> 25 kg / m2) smokers? 32 fasting male smokers were measured by indirect calorimetry prior to smoking and inhaling 2 containing 0 16mg nicotine (low nicotine) or 2 containing 1 74mg nicotine (high nicotine) cigarette after 30min REE , While measuring plasma concentrations of nicotine and norepinephrine. In the normal weight group, there was no significant change in REE and plasma catecholamines after inhaling nicotine smoke and in overweight group after inhaling nicotine or high nicotine smoke. In the normal body weight group, plasma norepinephrine increased after inhalation of high nicotine smoke, meanwhile REE increased by 72%. If plasma nicotine level was analyzed as a covariate, plasma norepinephrine Changes in concentration and REE were also insignificant, suggesting that the post-smoking thermogenic effect is due to elevated plasma nicotine concentrations. Body weight can have an effect on the thermogenic effect of nicotine, which is attenuated in overweight smokers. It is speculated that smokers with normal weight after smoking cessation, because no longer have smoking caused by energy consumption, may lead to weight gain