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单独应用肝素或合并应用口服抗凝剂的抗凝治疗已日益广泛使用于临床,在治疗某些疾病方面获得了显著的效果。同时,因抗凝治疗所致的出血并发症也逐渐引起医务人员的注意。本文收集了1945～1964年3862个抗凝治疗疗程中的资料,就其出血并发症的发生率、出血部位、与出血有关的原因等进行了分析讨论。 一、出血发生率:在3862个抗凝治疗疗程中,有263个疗程发生了一次或多次出血,占6.8％,其中重症出血为2％,轻症出血占4.8％,出血致死者4例,占0.1％,3例死于颅内出血,1例胃出血致命。
Anticoagulation therapy using heparin alone or in combination with oral anticoagulants has been increasingly used clinically and has achieved significant results in the treatment of certain diseases. At the same time, bleeding complications caused by anticoagulant therapy are also gradually attracted the attention of medical staff. This article collected data of 3862 anticoagulant treatments from 1945 to 1964, and analyzed the incidence of bleeding complications, bleeding sites and the causes of bleeding. First, the incidence of bleeding: 3862 anticoagulant therapy treatment, 263 courses occurred one or more times, accounting for 6.8%, of which 2% were severe bleeding, mild bleeding accounted for 4.8%, 4 cases of bleeding to death , Accounting for 0.1%, 3 died of intracranial hemorrhage, and 1 died of stomach bleeding.