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为观察依那普利(enalapril)临床疗效,54例原发性高血压患者分成两组,分别进行双盲及单盲随机对照研究。服药后4周,依那普利组从治疗前血压164.1/99.7mmHg(kPa21.88/13.30)降至139.0/87.7mmHg(kPa18.53/11.70)(p<0.001),降压幅度为25/12mmHg(kPa 3.35/1.60);对照组从治疗前血压165.6/98.0mmHg(kPa22.10/13.06)降至147.9/89.8mmHg(kPa 19.72/11.97)(p<0.001),降压幅度为17.7/8.2mmHz(kPa 2.40/1.09)。两组间血压无显著性差异。依那普利组降压有效率为69.7%,对照组为57.2%,两组间无显著性差异(p>0.05)。服药前后各实验室检查未见异常变化。依那普利组主要不良反应为头晕,头痛,嗜睡等。
To observe the clinical efficacy of enalapril, 54 patients with essential hypertension were divided into two groups: a double-blind and a single-blind randomized controlled study. After 4 weeks of treatment, the pre-treatment blood pressure decreased from 164.1 / 99.7mmHg (kPa21.88 / 13.30) to 139.0 / 87.7mmHg (kPa18.53 / 11.70) in enalapril group (p <0.001) (KPa 19.72 / 11.97) (kPa 19.72 / 11.97) (p <0.001), and the blood pressure decreased from 165.6 / 98.0mmHg (kPa22.10 / 13.06) before treatment to 147.79 / 89.8mmHg mmHz (kPa 2.40 / 1.09). There was no significant difference in blood pressure between the two groups. The effective rate of lowering blood pressure was 69.7% in enalapril group and 57.2% in control group, there was no significant difference between the two groups (p> 0.05). Before and after taking the test showed no abnormal changes in the laboratory. The main adverse reactions of enalapril group were dizziness, headache and drowsiness.