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ＣＤ４４变异型被认为与某些癌的发生和转移有关。作者的研究结果进一步表明：ＣＤ４４基因在脑转移瘤中的表达具有高度异质性；变异型外显子５和６（ｖ５／ｖ６）均匀存在于细胞群体中；而在那些邻近坏死区、肿瘤边缘和浸润性的部分癌细胞中，可见ｖ７～ｖ１０表达上调。该结果提示：ＣＤ４４表达的异质性，除与肿瘤细胞内在因素有关外，也受其周围的微环境影响；ＣＤ４４ｖ同种异构体的共存，可赋予转移细胞某些独特的能力，使其能有效地扩散至远隔器官，并在那里形成转移灶。
CD44 variants are thought to be involved in the carcinogenesis and metastasis of certain cancers. The authors further show that the expression of CD44 gene is highly heterogeneous in brain metastases; variant exons 5 and 6 (v5 / v6) are uniformly present in the cell population; whereas in those adjacent to the necrotic area, tumors In the marginal and invasive part of the cancer cells, the expression of v7 ~ v10 was observed. The results suggest that the heterogeneity of CD44 expression is not only related to intrinsic factors of tumor cells, but also influenced by the microenvironment around it. The coexistence of CD44v isoforms confers certain unique ability to transfer cells Can effectively spread to distant organs, and form metastases there.