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目的研究毛酸浆Physalis pubescensL.干燥宿萼的化学成分。方法利用硅胶柱色谱法、Sephadex LH-20凝胶柱色谱法、中压柱色谱及半制备高效液相色谱等方法分离纯化;通过核磁共振谱、质谱等光谱数据鉴定化合物结构。结果 分离得到10个化合物,分别鉴定为β-谷甾醇(1)、7,3′,4′-三甲基槲皮素(2)、5,4′-二羟基-3,7-二甲氧基黄酮(3)、山柰酚(4)、3-甲氧基-4-羟基苯甲酸(5)、2-羟甲基-5-羟基-γ-吡喃酮(6)、槲皮素(7)、商陆素(8)、木犀草素(9)、胡萝卜苷(10)。结论化合物2~6为首次从酸浆属植物中分离得到。
OBJECTIVE To study the chemical composition of Physalis pubescens L. dried persimmon. Methods The compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20 column chromatography, medium pressure column chromatography and semi-preparative high performance liquid chromatography. The structures of the compounds were identified by NMR, MS and other spectral data. Results Ten compounds were isolated and identified as β-sitosterol (1), 7,3 ’, 4’-trimethylquercetin (2), 5,4’-dihydroxy-3,7- Oxyflavone (3), kaempferol (4), 3-methoxy-4-hydroxybenzoic acid (5), 2-hydroxymethyl- (7), melatonin (8), luteolin (9), daucosterol (10). Conclusion Compounds 2 ~ 6 were isolated from Physalis for the first time.