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扩环酶，也叫脱乙酰氧基头孢菌素Ｃ合成酶，催化青霉素Ｎ 扩环生成脱乙酰氧基头孢菌素Ｃ，是头孢菌素生物合成中的关键酶。在真菌中它是一个双功能酶，同时具有扩环酶和羟化酶的活性；而在细菌中扩环和羟化却是由两个独立的酶来承担的。近年来，扩环酶被纯化成均一蛋白，有关它的性质、分子结构以及基因结构等方面的研究都取得了飞速发展，并不断地应用基因工程的技术探索其在抗生素生产上的应用。
Expanding enzyme, also known as deacetoxycephalosporin C synthetase, catalyzes the expansion of penicillin N to deacetoxycephalosporin C, which is a key enzyme in cephalosporin biosynthesis. In fungi it is a bifunctional enzyme that has both expandase and hydroxylase activities; however, expansion and hydroxylation in bacteria are carried out by two separate enzymes. In recent years, expandase has been purified into a homogeneous protein, its properties, molecular structure and gene structure have made rapid progress in the research, and continue to use genetic engineering technology to explore its application in the production of antibiotics.