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米非司酮与前列腺素(常用米索前列醇)配伍可应用于终止中期妊娠,不仅流产成功率高、安全性好且不良反应少。给药方法一般采用先口服米非司酮,随后间断给予米索前列醇,后者多采用阴道给药,但舌下含服等其他给药方式也有很高的实用性。对于两药的给药间隔常选择36～48h。但研究证实,间隔可缩减至24h甚至更短,米索前列醇则采用间隔3h给药1次,为减少不良反应的发生,米索前列醇的最佳剂量需进一步研究确定,使该种配伍方法更加完善。
Mifepristone and prostaglandin (commonly used misoprostol) compatibility can be applied to terminate the second trimester pregnancy, not only the high success rate of abortion, good safety and fewer adverse reactions. The method of administration is generally oral mifepristone, followed by intermittent administration of misoprostol, the latter with vaginal administration, but other sublingual administration and other modes of administration also have high practicability. For the interval between the two drugs often choose 36 ~ 48h. However, studies have shown that the interval can be reduced to 24 hours or less, misoprostol administered 3h intervals, in order to reduce the incidence of adverse reactions, the optimal dose of misoprostol needs further study to determine the compatibility Method is more perfect.