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端粒酶是含有RNA模板的核糖核蛋白,RNA模板用来合成端粒DNA。含有这种活性酶的细胞可逃避进行性端粒缩短而获得无限制的生长潜力。为了探讨包括良性脑膜瘤、复发神经胶质细胞瘤在内的颅脑肿瘤与预后的关系,作者对病理确珍的脑肿瘤样本进行了端粒酶活性检测,同时对肿瘤细胞的增殖活性进行了评价。 41份脑肿瘤样本来自于39例脑肿瘤病人手术切除标本,其中多形性胶质母细胞瘤20例,WHO病理分级为Ⅳ级(原发肿瘤14例,复发性肿瘤6例);未分化星形细胞瘤3例(Ⅲ级),分化好的星形细胞瘤4例(Ⅱ级),少突神经胶质细胞瘤2例,脑膜瘤9例(脑脊膜脑膜瘤4例,成纤维细胞脑膜瘤3例,过渡性脑膜瘤2
Telomerase is a ribonucleoprotein containing an RNA template that is used to synthesize telomeric DNA. Cells containing this active enzyme evade the progressive telomere shortening for unlimited growth potential. In order to investigate the relationship between the prognosis and brain tumor, including benign meningioma and recurrent glioma, the authors detected the telomerase activity in the brain tumor samples with definite pathology, and carried out the tumor cell proliferative activity Evaluation. Forty-one brain tumor samples were obtained from surgically excised 39 brain tumor patients, including 20 glioblastoma multiforme, WHO grade IV (14 cases of primary tumors and 6 cases of recurrent tumors); undifferentiated 3 cases of astrocytoma (grade Ⅲ), 4 cases of differentiated astrocytoma (Ⅱ), 2 cases of oligodendroglioma, 9 cases of meningioma (4 cases of meningiomas, fibroblasts 3 cases of meningioma, 2 cases of transitional meningioma