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根据癌症的遗传病因学的研究确认,人类某种先天性染色体异常与某一类型的癌症之间有着一定的联系。最引人注目的是第21号染色体的三体性(trisomy),即该病患儿的染色体比正常人多一个21号染色体。临床表现为先天愚型,又称21-三体综合症,或称Down氏综合症。根据大量资料现已确证,先天愚型与白血病之间有一定联系。1956年Kriyit和Good首先指出先天愚型发展为急性白血病的危险性增高。嗣后,Stewart等报告在677例因白血病而死亡的小儿中,先天愚型的患儿就占18例,
According to the genetic etiology of cancer research confirmed that some human congenital chromosomal abnormalities and a certain type of cancer have a certain relationship between. The most striking feature is trisomy on chromosome 21, where the child has one chromosome 21 more chromosomes than normal. Clinical manifestations of Down’s syndrome, also known as 21-trisomy syndrome, or Down’s syndrome. According to a large amount of information has now been confirmed, Down’s syndrome and leukemia have a certain relationship. 1956 Kriyit and Good first pointed out that the development of Down’s syndrome, the risk of developing acute leukemia increased. Subsequently, Stewart et al. Reported that among 677 children who died of leukemia, 18 were children with Down’s syndrome,