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目的：对应用氨磺必利与氯氮平联合对患有难治性神经分裂症疾病的患者实施治疗的临床效果进行研究。方法：选择在我院就诊的患有难治性神经分裂症疾病的患者80例，随机分为对照组和治疗组，平均每组40例。采用氯氮平对对照组患者实施治疗；采用氨磺必利与氯氮平联合对治疗组患者实施治疗。结果：治疗组患者精神异常症状消失时间和精神分裂药物治疗总时间明显短于对照组；难治性神经分裂症疾病药物治疗效果明显优于对照组。结论：应用氨磺必利与氯氮平联合对患有难治性神经分裂症疾病的患者实施治疗的临床效果非常明显。“,”Objective To apply amisulpride and clozapine combined with clinical effects of treatment for patients with refractory schizophrenia implementation disease research. Methods In our hospital patients with refractory schizophrenia disease, 80 patients were randomly divided into control and treatment groups, with an average 40 cases each. The use of clozapine on treatment for patients in the control group;the use of amisulpride and clozapine in the treatment group were jointly administer treatment. Results psychosis symptoms disappear time and treated schizophrenia drug treatment was significantly shorter overall than the control group;refractory schizophrenia Disease Drug treatment is better than the control group. Conclusion amisulpride and clozapine plus for patients with refractory schizophrenia disorders implementation of clinical treatment effect is very obvious.