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The growth of Staphylococcus aureus under the action of six kinds of Schiff bases(A,B,C,D,E,F) was studied by means of microcalorimetry. Growth constant k and inhibition ratio I were calculated. Also,the antibacterial activity,the action characteristics and the structure-activity relationships of the compounds on S. aureus were analyzed. Results indicate that B,F show good antibacterial activity(IC50:293.6 mg · L-1 and 307.8 mg · L-1) ,D,E show moderate antibacterial activity(IC50:966.3 mg · L-1 and 1 126.7 mg · L-1) ,and A,C just show weak antibacterial activity(IC50 >1 200 mg · L-1) . The I-c curves mainly present a straight line shape for B,D,E and F,but an inverse “S” shape for A and C. Structure-activity relationships analysis suggests that the species and position of the substituents determine the antibacterial activity of these Schiff bases,and the charge density distribution is one of the most important influencing factors.
The growth of Staphylococcus aureus under the action of six kinds of Schiff bases (A, B, C, D, E, F) was studied by means of microcalorimetry. Growth constant k and inhibition ratio I were calculated. Also, the antibacterial activity, Results indicate that B, F show good antibacterial activity (IC50: 293.6 mg · L-1 and 307.8 mg · L-1), D, E show moderate antibacterial activity (IC50: 966.3 mg · L -1 and 1 126.7 mg · L -1), and A, C just show weak antibacterial activity (IC 50> 1 200 mg · L -1). The Ic curves mainly present a straight line shape for B, D, E and F, but an inverse “S ” shape for A and C. Structure-activity relationships analysis suggests that the species and position of the determine the antibacterial activity of these Schiff bases, and the charge density distribution is one of the most important influencing factors