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目的研究CTL、NK及TIDC在胃腺癌组织中的分布情况及对病人生存与预后的影响。方法将CD8作为细胞毒T淋巴细胞(CTL)的标记物,CD56作为自然杀伤细胞(NK)的标记物,S-100作为肿瘤浸润树突状细胞(TIDC)的标记物,应用免疫组织化学方法检测肿瘤组织中CTL、NK及TIDC的分布和浸润情况。结果 80例胃腺癌中,CTL无-轻度浸润的48例,5年生存率为38%;显著浸润的32例,5年生存率为63%;NK细胞无-轻度浸润的50例,5年生存率42%,显著浸润的30例,5年生存率为63%;TIDC无-轻度浸润的52例,5年生存率为37%;TIDC显著浸润的28例,5年生存率为57%;NK/T及TIDC同时显著浸润的24例,5年生存率为67%;无-轻度浸润的32例,5年生存率为47%,经Log-rank检验,NK/T及TIDC显著浸润组和无-轻度浸润组的5年生存率差异有统计学意义(P=0.00)。结论胃腺癌组织中CTL、NK及TIDC显著浸润组的预后和生存时间明显好于轻度浸润组。
Objective To study the distribution of CTL, NK and TIDC in gastric adenocarcinoma and its impact on the survival and prognosis of patients. Methods CD8 was used as a marker of cytotoxic T lymphocytes (CTL), CD56 as a marker of natural killer (NK) cells and S-100 as a marker of tumor-infiltrating dendritic cells (TIDC). Immunohistochemistry Detection of tumor tissue CTL, NK and TIDC distribution and infiltration. Results In 80 cases of gastric adenocarcinoma, there were 48 cases of CTL without - mild infiltration, the 5-year survival rate was 38%. Significant infiltration of 32 cases, 5-year survival rate was 63%; NK cells without mild infiltration in 50 cases, 5-year survival rate was 42%, significant infiltration of 30 cases, 5-year survival rate was 63%; TIDC-mild infiltration of 52 cases, 5-year survival rate was 37%; TIDC significant infiltration of 28 cases, 5-year survival rate , And 57%. In 24 cases with significant infiltration of NK / T and TIDC, the 5-year survival rate was 67%. There were 32 cases without mild infiltration and the 5-year survival rate was 47%. Log-rank test showed that NK / T There was a significant difference in 5-year survival between TIDC-infiltrating group and non-infiltrating group (P = 0.00). Conclusion The prognosis and survival of CTL, NK and TIDC in gastric adenocarcinoma were significantly better than those in mild infiltration group.