【摘 要】
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Objective: To study the cellular immunity function of patients with early syphilis and the effects on immune modifiers Esberitox N or IFN.Methods: T-lymphocyte
【机 构】
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Guangzhou Institute of Dermatology, Guangzhou, 510095. China“,”Department of Dermatology, the Third
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Objective: To study the cellular immunity function of patients with early syphilis and the effects on immune modifiers Esberitox N or IFN.Methods: T-lymphocyte subpopulations of the peripheral blood in 44 patients with syphilis and 40 healthy controls were examined by flow cytometry.Results: The number of CD4+ cells and the CD4+/CD8+ ratio in patients with syphilis were found to be significantly lower than those in the control (P＜0.01), while the number of CD8+ cells was higher than that in the control (P＜0.01). The CD4+/CDs+ ratio in those with active disease was lower than that in those who had been cured (P＜0.05). The CD4+ count and the CD4+/CDs+ ratio in those treated with antibiotics alone (Penicillin G or Cephalosporins) were lower than those treated with both antibiotics and immunomodulators (P＜0.05).Conclusions: Cellular immunity in the patients with early syphilis was prominently suppressed, and treatment with immunomodulators may be helpful for the recovery of cellular immunity of these patients.
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