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利用性激素加速或减慢卵子运行,造成输卵管峡部功能闭锁或松弛,观察兔输卵管、子宫组织PGE_1、PGF_(2α)及E/F比值的变化。实验分对照组、孕激素(MQG)组和雌激素(ECP)组。1.三组各部组织PGE_1、PGF_(2α)含量比较:壶-峡交接部、远峡部、近峡部含量最高,子宫次之,壶腹部最低。2.孕激素(MQG)和雌激素(ECP)均能使兔交配后28小时输卵管PGE_1、PGF_(2α)升高,孕激素使PGE_1上升的程度较大,而雌激素使PGF_(2α)上升的程度较大。E/F比值:对照组E/F接近1,孕激素组E/F大于1,雌激素组E/F小于1。3.三组兔交配后28小时与76小时峡部PGE_1、PGF_(2α)含量变化比较:对照组,PGE_1无明显变化,PGF_(2α)则76小时比28小时降低40～50%(76小时约有20%卵进入子宫);孕激素组,PGF_(2α)无明显变化,PGE_128小时比对照组及雌激素组高(28小时有75%卵比对照组提前二天进入子宫,峡部收缩频率低),76小时壶-峡交接部、远峡部比28小时降低约40%,接近对照组28小时PGE_1水平;雌激素组,PGE_176小时远峡、近峡部比28小时降20～40%,而PGF_(2α)在28小时较高水平上远峡部又继续上升15%(此时卵全部停留在输卵管内,比对照组延迟2天进入子宫,峡部收缩频率高)。两种不同类型激素激发兔输卵管前列腺素含量的变化,在时间上符合两种不同激素对兔卵子运行和输卵管峡部收缩频率产生的相反效应,这一结果似乎显示输卵管闭锁功能与卵子运行之间的关系不仅与PGS的量有关,而且与PGE_1、PGF_(2α)的比值有关,两者关系可能通过PGE和PGF平衡调节。
The use of sex hormones to accelerate or slow down the operation of the egg, causing tubal isthmus function atresia or relaxation, observed tubal, uterine tissue PGE 1, PGF 2α and E / F ratio changes. Experimental control group, progesterone (MQG) group and estrogen (ECP) group. 1.Comparison of PGE_1, PGF_ (2α) contents among the three groups: the content of PGE_1, the distal isthmus and the proximal isthmus were the highest, followed by the uterus, and the lowest in the ampulla. Both estrogen (ECP) and estrogen (ECP) increased the PGE_1, PGF_ (2α) in tubal 28 hrs after ovulation, while the levels of PGE_1 increased with progesterone, while estrogen increased PGF_ (2α) To a large extent. The ratio of E / F in control group was close to 1, E / F in progesterone group was greater than 1, and E / F in estrogen group was less than 1.3. PGE_1, PGF_ (2α) Compared with control group, there was no obvious change of PGE_1, PGF_ (2α) decreased 40 ~ 50% in 76 hours than in 28 hours (about 20% of eggs enter the uterus in 76 hours); there was no significant change in progesterone group and PGF_ (2α) , PGE_128 hours higher than the control group and the estrogen group (75% of the eggs in 28 hours into the uterus two days earlier than the control group, the isthmus contraction frequency is low), 76 hours pot - Gap junction, the isthmus than the 28 hours to reduce about 40% Close to the control group 28 hours PGE_1 level; estrogen group, PGE_176 hours in the remote gorge, near the isthmus 20 to 40% lower than 28 hours, and PGF 2α in the 28 hours higher level of the isthmus continued to rise 15% (at this time All eggs remain in the fallopian tube, than the control group into the uterus for 2 days, the isthmus high contraction frequency). The changes in the prostaglandin content in the fallopian tubes induced by two different types of hormones coincided in time with the opposite effects of two different hormones on the operation of the ovum and on the frequency of the isthmic collapse of the fallopian tube. This result seems to suggest that the function of the tubal atresia The relationship was not only related to the amount of PGS but also to the ratio of PGE_1 and PGF_ (2α), and the relationship between them may be regulated by the balance of PGE and PGF.