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目的 :检测雌激素受体 (ER)、孕激素受体 (PR)在正常子宫颈的分布 ,并探讨ER和PR的表达状态与宫颈鳞癌的发生发展及预后的关系。方法 :采用SP免疫组化方法对 2 1例正常宫颈 ,40例宫颈上皮内瘤变 (CIN)及 71例浸润性宫颈鳞癌进行ER、PR检测。结果 :正常宫颈ER、PR主要在鳞状上皮、腺上皮及间质细胞核表达 ,且三者表达状态基本一致 ,CIN鳞状上皮及浸润性宫颈鳞癌ER、PR核表达率明显降低。结论 :ER、PR核表达下调或缺失可能是宫颈鳞癌发生的一重要机制。
Objective: To detect the distribution of estrogen receptor (ER) and progesterone receptor (PR) in normal cervix and to investigate the relationship between the expression of ER and PR and the occurrence, development and prognosis of cervical squamous cell carcinoma. Methods: The SP and SP immunohistochemical methods were used to detect ER, PR in 21 normal cervix, 40 cervical intraepithelial neoplasia (CIN) and 71 invasive cervical squamous cell carcinoma. Results: The expression of ER and PR in normal cervix was mainly in the squamous epithelium, glandular epithelium and interstitial nucleus. The expressions of ER and PR in squamous epithelium of invasive cervical squamous cell carcinoma and invasive cervical squamous cell carcinoma were significantly decreased. Conclusion: The down-regulation or deletion of ER and PR nuclear may be an important mechanism of cervical squamous cell carcinoma.