干扰素系统与干扰素的合成

• 作 者: 梁希若 郑志坚
• 出 处: 广医通讯
• 发表日期: 1979年03期
• 关键词: 干扰素 细胞内生 鸡胚绒毛尿囊膜 干扰现象 流感病毒 病毒干扰现象 抗病毒 干扰素诱生剂 诱生剂 Interferon

一、前言1935年就已发现一种病毒在动物体内或组织培养细胞内生长时,会干扰另一种病毒的复制,这就是病毒的干扰现象。1957年 Isaacs 和 Lindenmann 等在研究病毒的干扰现象时发现;用加热灭活的流感病毒处理鸡胚绒毛尿囊膜细胞后,在其培养液中出现一种能明显抑制流感病毒和仙合病毒的物质,称为干扰素(Interferon)。而且,很快就了解到它在动物体内可产生抗病毒作用。大多数的病毒干扰现象实例都是通过干扰素来体现的。由于干扰素具有对抗病毒的作用,因此,从发现开始很快就引起了世界医学

I. INTRODUCTION It has been found in 1935 that a virus interferes with the replication of another virus when it is grown in animal or tissue culture cells. This is the virus’s interference. In 1957, Isaacs and Lindenmann et al found that when the viruses were interfered, the treatment of chick chorioallantoic membrane cells with heat-inactivated influenza virus resulted in the appearance of a Substance, known as Interferon (Interferon). And, soon learned that it can produce antiviral effects in animals. Most of the examples of virus interference are reflected by the interferon. Since interferon has an anti-viral effect, it quickly caught the eye of world medicine