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目的:探讨思密达防治阿奇霉素引起胃肠道不良反应的效果。方法:从我院收治的呼吸道感染患儿中选取114例作为临床研究对象。所有患者均采用阿奇霉素注射液缓慢静滴治疗。随机分组:观察组57例,在使用阿奇霉素之前口服思密达;对照组57例,单纯使用阿奇霉素进行治疗,不加用思密达。比较两组患儿的胃肠道不良反应。结果:观察组患儿的胃肠道不良反应发生率(10.53%)明显低于对照组(26.32%),结果对比差异显著(P<0.05)。结论:在应用阿奇霉素之前预防性应用思密达可有效预防胃肠道不良反应的发生。
Objective: To investigate the effect of Smectite against azithromycin-induced gastrointestinal adverse reactions. Methods: 114 cases of children with respiratory tract infection admitted to our hospital as clinical research object. All patients were treated with azithromycin injection slowly and intravenously. Randomly divided into groups: observation group 57 cases, before taking azithromycin oral metaset; control group of 57 cases, the simple treatment with azithromycin, without using Smectite. Gastrointestinal adverse reactions in both groups were compared. Results: The incidence of gastrointestinal adverse reactions (10.53%) in observation group was significantly lower than that in control group (26.32%), the difference was significant (P <0.05). Conclusion: The prophylactic application of Smecta before azithromycin can effectively prevent the occurrence of gastrointestinal adverse reactions.