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白细胞介素6(IL—6)是由T细胞等免疫活性细胞产生的多功能淋巴因子,具有诱导B细胞增殖、分化并产生抗体,刺激肝细胞产生急性期蛋白,诱导T细胞表达IL-2受体等多种作用。本文观察单纯性肾病(INS)患儿外周血淋巴细胞体外产生IL-6活性水平,并分析IL-6与患儿免疫球蛋白G的关系,以探讨INS低IgG血症的可能机理。
Interleukin-6 (IL-6) is a multifunctional lymphokine produced by immunocompetent cells such as T cells. It induces proliferation, differentiation and antibody production of B cells, stimulates the production of acute phase proteins in hepatocytes, and induces the expression of IL-2 Receptors and other effects. In this paper, IL-6 activity in peripheral blood lymphocytes of children with simple nephropathy (INS) was observed and the relationship between IL-6 and immunoglobulin G in children was analyzed to explore the possible mechanism of low serum IgG in patients with INS.