论文部分内容阅读
Objectives To determine the change of plasma leptin levels and the correlation between hyperleptinaemia and insulin resistance or TNF-o in patients with congestive heart failure (CHF). Methods The levels of plasma leptin, fasting plasma insulin (FINS) and TNF-α in 64 male patients with CHF and 30 healthy male people were measured by ELISA. Body mass index (BMI), waist/hip ratio (WHR) and insulin resistance index (Homa-IR) were calculated respectively. Results The plasma leptin levels in CHF group were higher compared with control group (P＜0.001). There was a increased trend of plasma leptin levels in CHF group with the increase of NYHA class (rs=0.884, P＜0.001); according to different etiology ,there was no significant difference of plasma leptin levels in CHF group (P＞0.05); FINS,Homa-IR and TNF-o levels in CHF group were higher than in control group (all P＜0.001); in CHF group plasma leptin levels correlated with FINS (r=0.652,P＜0.001),Homa-IR (r=0.561,P＜0.001) and TNF-α (r=0.629,P＜0.001); in multiple stepwise regression analysis BMI, FINS and TNF-α were isolated factors affecting plasma leptin levels in CHF group, Y=-3.466+0.456 (BMI)+ 0.162 (FINS)+4.487(TNF-α), F=38.405,P＜0.001. Conclusions plasma leptin levels were raised and correlated with disease severity in patients with CHF; FINS and TNF-α were isolated factor affecting plasma leptin level in CHF patients; hyperleptinaemia may play a role in the pathophysiology of CHF such as catabolic process and activation of neurohormonal.