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骨吸收无论是在口腔内科、口腔外科、口腔正畸科还是在口腔修复科的疾病与治疗中都是普遍存在的问题,例如,牙周炎的主要病理变化之一就是牙槽骨的吸收破坏,根尖周炎、拔牙后的牙槽嵴、颌骨肿瘤、囊肿,矫正畸形牙,还有口腔修复中的牙槽嵴等同样也存在着骨吸收问题。对于骨吸收的发病机理至今仍不清楚,是一个急待解决的问题。破骨细胞是骨吸收的主要作用者,因而从破骨细胞着手,弄清其结构和生物学功能,对骨吸收机理的探
Bone resorption is a common problem not only in oral medicine, oral surgery, orthodontics, but also in the field of oral prosthetics. For example, one of the main pathological changes of periodontitis is the destruction of alveolar bone , Periapical periodontitis, alveolar ridge after tooth extraction, jaw tumor, cyst, orthodontic tooth, as well as the alveolar ridge in oral repair, there are also bone resorption problems. The pathogenesis of bone resorption is still not clear, is an urgent problem to be solved. Osteoclasts are a major contributor to bone resorption, and therefore begin with osteoclasts, clarifying their structural and biological functions, exploring the mechanism of bone resorption