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应用 Greiss 反应测定35例育龄非孕妇女、32例正常晚期妊娠妇女及32例妊高征患者的血清一氧化氮含量,以探讨一氧化氮在正常妊娠及妊高征发病机理中的作用。结果:正常晚期妊娠妇女血清一氧化氮含量明显高于育龄非孕妇女(P<0.001),而妊高征患者的血清一氧化氮含量明显低于正常孕妇(P<0.001)。表明:妊娠期一氧化氮合成增加对维持正常妊娠具有重要意义;妊高征的发生可能与妊娠期一氧化氮合成减少有关。
Serum nitric oxide levels in 35 pregnant women of childbearing age, 32 normal late pregnant women and 32 patients with PIH were measured by Greiss reaction to explore the role of nitric oxide in the pathogenesis of normal pregnancy and pregnancy induced hypertension. Results: The levels of serum nitric oxide in normal pregnant women were significantly higher than those in non-pregnant women of reproductive age (P <0.001), while the levels of serum nitric oxide in pregnant women with PIH were significantly lower than those in normal pregnant women (P <0.001). It is indicated that the increase of nitric oxide synthesis during pregnancy is of great significance for the maintenance of normal pregnancy. The incidence of PIH may be related to the decrease of nitric oxide synthesis during pregnancy.