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Aim:To investigate whether the measurement of serum zinc may improve the detection of prostate cancer(PCa)inmen who had total prostate-specific antigen(PSA)levels higher than 4.1 ng/mL.Methods:A mass screening for PCaof 3940 men over 50 years old was undertaken using total serum PSA.Of the 190 men(4.8 %)with elevated PSA,143(3.6 %)underwent a transrectal ultrasonography(TRUS)-guided biopsy of the prostate,and 42 men(1% of total and29.3 % of men undergoing biopsy)were found to have cancer.The areas under the receiver operating characteristiccurves(ROC-AUC)were used to compare the diagnostic power of cancer detection by means of serum zinc,and freePSA/total PSA ratio(f/t).Results:The men with levels of serum zinc that ranged from 40 ng/mL-60 ng/mL,had anage-adjusted odds ratios(OR)of 5.0.A cutoff value of 100 μg/mL for-serum zinc concentration provided a sensitivityof 90.5 % and a specificity of 32.7 % in elevated PSA range,and a sensitivity of 93.3 % and specificity of 27.1% ingray zone,respectively.In the gray zone ranges of 4.1 ng/mL-10.0 ng/mL,the ROC-AUC for zinc was 73.0 %higher than 62.7 % of f/t PSA ratio and 56.7 % of total PSA.Conclusion:PCa displays a lower serum zincconcentration.The measurement of zinc levels improves PCa detection in the gray zone compared with the f/t PSAratio and total PSA.
A investigate whether the measurement of serum zinc may improve the detection of prostate cancer (PCa) inmen who had total prostate-specific antigen (PSA) levels higher than 4.1 ng / mL. Methods: A mass screening for PCaof 3940 men over 50 years old was taken using total serum PSA. Of the 190 men (4.8%) with elevated PSA, 143 (3.6%) underwent a transrectal ultrasonography (TRUS) -guided biopsy of the prostate, and 42 men (1% of total and 29. 3% of men undergoing biopsy) were found to have cancer. These sections under the receiver operating characteristic curves (ROC-AUC) were used to compare the diagnostic power of cancer detection by means of serum zinc, and free PSA / total PSA ratio (f / Results: The men with levels of serum zinc that ranged from 40 ng / mL to 60 ng / mL, had anage-adjusted odds ratios (OR) of 5.0. A cutoff value of 100 μg / mL for-serum zinc concentration provided a sensitivity of 90.5% and a specificity of 32.7% in elevated PSA range, and a sensitivity of 93.3% and specificity of 27.1% ingray zon the ROC-AUC for zinc was 73.0% higher than 62.7% of f / t PSA ratio and 56.7% of total PSA. Conlusion: PCa displays a lower serum zinc concentration. The measurement of zinc levels improves PCa detection in the gray zone compared with the f / t PSAratio and total PSA.