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热休克蛋白(heat shock protein,HSP)一直被认为是细胞内蛋白质,在胞内通过帮助蛋白质正确折叠、组装以及促进变性蛋白质降解而发挥生物学功能。HSP能被主动地分泌到胞外,成为细胞外HSP(extracellularHSPe,HSP),但其分泌及作用机制尚未定论。HSP偶然释放到外周循环是通过细胞坏死,生理性释放则是通过活化分泌系统。HSP有一种重要的前炎症因子可通过相同的分泌系统分泌,抗HSP自身抗体可以促进HSP的细胞因子样、辅佐样活性,抗HSP自身抗体与HSP或者HSP受体交联是放大HSP免疫信号作用的可能机制。
Heat shock proteins (HSPs) have long been recognized as intracellular proteins that exert their biological functions intracellularly by helping proteins to properly fold, assemble and promote denatured protein degradation. HSP can be proactively secreted extracellularly and become an extracellular HSP (HSP), but the mechanism of its secretion and its role remains unclear. Accidental release of HSP into the peripheral circulation is through cell necrosis, and physiological release is through activation of the secretory system. HSP An important proinflammatory cytokine secretes through the same secretory system. Anti-HSP autoantibodies promote cytokine-like and accessory-like activities of HSPs. Anti-HSP autoantibodies are cross-linked to HSP or HSP receptors to amplify HSP signaling. Possible mechanism.