论文部分内容阅读
甲氟喹(Mefloquine)是一种新合成的抗疟药,对那种对氯喹和喹咛具有抗药性的镰状疟原虫(Plasmdium faleiparunl)有效,最近它已被用于泰国临床.泰国急性恶性疟男性成年患者和瑞士健康男性成年志愿者各6人,相继口服盐酸甲氟喹片和〔~2H〕-盐酸甲氟喹溶液(250mg游离碱),对于泰国患者,其剂量相当于4.8±0.6mg/kg,对瑞士健康者为3.5±0.1mg/kg.用GC-MS技术,根据标记和非标记药物碎片质量的差异,同时测定受试者血浆中〔~2H〕-甲氟喹及甲氟喹的浓度.用加权非线性回归分析,按一
Mefloquine is a newly synthesized antimalarial drug that is effective against Plasmdium faleiparunl, a drug that is resistant to chloroquine and quizalotole, and has recently been used in clinical practice in Thailand. Acute Malignancies in Thailand 6 adult malaria patients and 6 healthy adult Swiss volunteers each received oral mefloquine hydrochloride and [~ 2H] -mefloquine hydrochloride solution (250 mg free base) for Thai patients at doses equivalent to 4.8 ± 0.6 mg / kg, and 3.5 ± 0.1 mg / kg for healthy Swiss.Using GC-MS technique, the contents of [-2H] -mefloquine and A Fluoroquine concentration. Using weighted non-linear regression analysis, press one