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目的深入探讨重楼皂甙杀灭血吸虫尾蚴及其阻止尾蚴侵入皮肤的防护效果。方法人工逸放的血吸虫尾蚴，挑入不同浓度的药液中，作用一定时间，分别判定其死亡或感染小白鼠；涂肤防护试验，小白鼠涂擦重楼皂甙油膏或溶液，待干，泥水浆机械摩擦，感染血吸虫尾蚴。结果血吸虫尾蚴接触２０ｍｇ／Ｌ和４０ｍｇ／Ｌ重楼皂甙液，５分钟和１５分钟尾蚴死亡率均为１００％；人工感染小白鼠，５ｍｇ／Ｌ的防护率为６１３２％、２０ｍｇ／Ｌ的防护率达１００％，相同浓度１５ｍｇ／Ｌ，尾蚴接触５分钟的小白鼠防护率为８５８０％；１５分钟和３０分钟为９９３３％和９９４％。小白鼠涂擦重楼皂甙油膏、溶液的防护率为９８０４％～１００％。结论重楼皂甙具有较强的杀灭尾蚴的作用，且有较强的防护效果。
Objective To explore the protective effect of polysaccharide from Saponins of Paeonia lactiflora against the invasion of cercariae of Schistosoma japonicum and the prevention of its invasion into the skin by cercariae. Methods Human cercaria larvae were randomly collected and challenged with different concentrations of medicinal solution for a certain period of time to determine whether they were dead or infected with mice. Skin protection tests were conducted in mice by rubbing the plaster or solution of resplendent saponins, Slurry slurry friction, infection of schistosome cercariae. Results Schistosoma japonicum cercariae exposure to 20mg / L and 40mg / L resveratrol saponin 5 minutes and 15 minutes cercariae mortality were 100%; artificially infected mice, 5mg / L protection rate of 6132%, 20mg / L of Protection rate of 100%, the same concentration of 15mg / L, cercariae exposure to mice 5 minutes protection rate of 85 80%; 15 minutes and 30 minutes was 99 33% and 99 4%. Mouse rubbed resplendent ointment, the protective rate of the solution was 98 04% to 100%. Conclusion Polygonum saponins has a strong role in killing cercariae, and has a strong protective effect.