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各种有机磷杀虫剂都有抑制胆硷酯酶(ChE)活性的作用。胆硷酯酶活力的测定,对急性有机磷中毒的诊断具有重要的意义,但是在较长期的接触有机磷杀虫剂时,由于机体对有机磷杀虫剂产生了耐受性,因而机体能够适应较低水平的胆硷酯酶活性状态。例如有人曾报告乙酰胆硷酯酶活力甚至降低至正常值的5％时,仍可不出现症状,因此胆硷酯酶活力测定,对诊断有机磷杀虫剂慢性中毒的意义如何,值得探讨。
Various organophosphorus insecticides have the effect of inhibiting cholinesterase (ChE) activity. Determination of cholinesterase activity, the diagnosis of acute organophosphate poisoning is of great significance, but in the longer-term exposure to organophosphate insecticides, due to organism to organophosphate insecticide resistance, so the body can Adapt to lower levels of cholinesterase activity status. For example, it has been reported that the acetylcholinesterase activity even reduced to 5% of normal when the symptoms can still occur, so the determination of cholinesterase activity for the diagnosis of chronic organophosphate insecticide significance, worth exploring.