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目的了解金钗石斛对老龄小鼠的抗氧化作用。方法将40只雄性老龄小鼠随机分为4组:即空白对照组、低剂量组、中剂量组和高剂量组。低、中、高剂量组分别经口灌胃给予0.06、0.12和0.36g/kg.bw金钗石斛溶液,空白对照组给予同体积的蒸馏水。持续给药30d后,测定各组小鼠血中丙二醛(MDA)含量、超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)活力。结果高剂量组小鼠血中MDA水平下降,与对照组相比,差异有统计学意义(P<0.05),SOD活力和GSH-Px活力水平升高,且与对照组相比,差异均有统计学意义(P<0.05)。结论金钗石斛对老龄小鼠具有抗氧化作用。
Objective To understand the antioxidative effect of Dendrobium nobile on aging mice. Methods Forty male old mice were randomly divided into four groups: blank control group, low dose group, middle dose group and high dose group. The low, medium, and high dose groups were orally administered with 0.06, 0.12, and 0.36 g/kg.bw respectively, and the blank control group was given the same volume of distilled water. After 30 days of continuous administration, blood malondialdehyde (MDA) content, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity were measured in each group of mice. Results Compared with the control group, the MDA level in the blood of the high-dose group decreased significantly (P<0.05), and the SOD activity and GSH-Px activity increased. Compared with the control group, the differences were both significant. Statistical significance (P<0.05). Conclusion Dendrobium nobile has antioxidative effects on old mice.